Publication Name	World Journal of Immunology
Manuscript ID	9746
Country	United States

Received	2014-02-26 10:38
Peer-Review Started	2014-02-27 16:24
To Make the First Decision	2014-03-12 16:40
Return for Revision	2014-03-20 20:46
Revised	2014-04-02 01:28
Second Decision	2014-06-18 14:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-18 15:16
Articles in Press	2014-06-18 15:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-22 15:44
Publish the Manuscript Online	2014-07-27 18:55

ISSN	2219-2824 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Review
Article Title	Lysosomal acid lipase is critical for myeloid-derived suppressive cell differentiation, development, and homeostasis
Manuscript Source	Invited Manuscript
All Author List	Cong Yan and Hong Du
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health CA138759 National Institutes of Health CA152099(to Yan C) National Institutes of Health HL087001(to Du H) National Institutes of Health HL-061803 National Institutes of Health HL-067862 (to Yan C and Du H)
Corresponding Author	Dr. Cong Yan, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 975 W Walnut Street, IB424G, Indianapolis, IN 46202, United States. coyan@iupui.edu
Key Words	Lysosomal acid lipase; Myeloid-derived suppressor cells; immunosuppression; Myeloid-derived suppressive cell development; Hematopoiesis
Core Tip	Neutral lipid metabolism is essential for myeloid cell proliferation and differentiation. This review summarizes the most recent discoveries that lysosomal acid lipase (LAL), an enzyme hydrolysing cholesteryl esters and triglycerides in lysosomes, plays a critical role in myeloid-derived suppressive cells (MDSCs) development, differentiation, and immune suppressive function. Both LAL knock-out and myeloid specific rescue of LAL knock-out mice are used in the studies. Doxycycline-inducible bitransgenic mouse models of LAL downstream genes are also generated to study MDSCs malformation and malfunction. The molecular pathways/mechanisms to connect LAL and MDSCs are characterized by microarray analyses of gene transcriptional profiles.
Publish Date	2014-07-27 18:55
Citation	Yan C, Du H. Lysosomal acid lipase is critical for myeloid-derived suppressive cell differentiation, development, and homeostasis. World J Immunol 2014; 4(2): 42-51
URL	http://www.wjgnet.com/2219-2824/full/v4/i2/42.htm
DOI	http://dx.doi.org/10.5411/wji.v4.i2.42

Full Article (PDF)	WJI-4-42.pdf
Full Article (Word)	WJI-4-42.doc
Manuscript File	9746-Review.docx
Answering Reviewers	9746-Answering reviewers.pdf
Copyright License Agreement	9746-Copyright assignment.pdf
Peer-review Report	9746-Peer review(s).pdf
Scientific Misconduct Check	9746-CrossCheck.jpg
Scientific Editor Work List	9746-Scientific editor work list.pdf