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11/3/2016 3:50:00 PM | Browse: 379 | Download: 670
Publication Name World Journal of Hematology
Manuscript ID 28904
Country/Territory Australia
2016-07-20 17:25
Peer-Review Started
2016-07-21 17:07
To Make the First Decision
2016-08-04 16:30
Return for Revision
2016-08-05 12:25
2016-08-10 10:09
Second Decision
2016-09-12 10:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-09-22 14:20
Articles in Press
2016-09-22 14:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-10-31 16:09
Publish the Manuscript Online
2016-11-03 15:47
ISSN 2218-6204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Hematology
Manuscript Type Basic Study
Article Title P2X7 receptor activation causes phosphatidylserine exposure in canine erythrocytes
Manuscript Source Invited Manuscript
All Author List Megan Faulks, Tracey A Kuit, Reece A Sophocleous, Belinda L Curtis, Stephen J Curtis, Lisa M Jurak and Ronald Sluyter
Funding Agency and Grant Number
Funding Agency Grant Number
Centre for Medical and Molecular Bioscience (University of Wollongong)
American Kennel Club Canine Health Foundation
Corresponding author Ronald Sluyter, PhD, Associate Professor, School of Biological Sciences, University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia. rsluyter@uow.edu.au
Keywords Adenosine triphosphate; Dog; P2X1 receptor; P2X7 receptor; Phospholipid; Purinergic receptor; Red blood cells
Core Tip Phosphatidylserine (PS) exposure in erythrocytes has potential roles in erythrocyte clearance and thrombus formation. Activation of the ATP-gated P2X7 receptor channel induces PS exposure in human erythrocytes, but whether this process occurs in erythrocytes from other mammals remained hitherto unknown. The current study shows that extracellular ATP causes PS exposure in dog erythrocytes from 13 pedigrees and seven crossbreeds. Notably, the current study shows that this process is mediated by P2X7 activation. These results suggest that P2X7-mediated PS exposure on erythrocytes may have important roles in red blood cell biology in dogs.
Publish Date 2016-11-03 15:47
Citation Faulks M, Kuit TA, Sophocleous RA, Curtis BL, Curtis SJ, Jurak LM, Sluyter R. P2X7 receptor activation causes phosphatidylserine exposure in canine erythrocytes. World J Hematol 2016; 5(4): 88-93
Url http://www.wjgnet.com/2218-6204/full/v5/i4/88.htm
DOI http://dx.doi.org/10.5315/wjh.v5.i4.88
Full Article (PDF) WJH-5-88.pdf
Full Article (Word) WJH-5-88.doc
Manuscript File 28904-Review.docx
Answering Reviewers 28904-Answering reviewers.pdf
Audio Core Tip 28904-Audio core tip.m4a
Biostatistics Review Certificate 28904-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 28904-Conflict-of-interest statement.pdf
Copyright License Agreement 28904-Copyright assignment.pdf
Data Sharing Statement 28904-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 28904-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160720141722.docx
Institutional Animal Care and Use Committee Approval Form or Document 28904-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 28904-Institutional review board statement.pdf
Peer-review Report 28904-Peer-review(s).pdf
Scientific Misconduct Check 28904-Scientific misconduct check.pdf
Scientific Editor Work List 28904-Scientific editor work list.pdf