Publication Name	World Journal of Gastroenterology
Manuscript ID	3411
Country	Czech Republic

Received	2013-04-28 08:55
Peer-Review Started	2013-04-28 21:19
To Make the First Decision	2013-05-23 17:13
Return for Revision	2013-06-02 19:53
Revised	2013-07-18 18:03
Second Decision	2013-08-08 19:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-08-09 01:02
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-29 15:43
Publish the Manuscript Online	2013-10-15 17:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	New insights in bilirubin metabolism and their clinical implications
Manuscript Source	Invited Manuscript
All Author List	Eva Sticova and Milan Jirsa
Funding Agency and Grant Number	Funding Agency Grant Number Project (Ministry of Health, Czech Republic) for Development of Research Organization 00023001
Corresponding Author	Sticova Eva, MD, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 14021 Prague 4, Czech Republic. eva.sticova@ikem.cz
Key Words	Hyperbilirubinemia; Hereditary jaundice; UGT1A1; ABCC2; Organic anion transporting polypeptide 1B1; Organic anion transporting polypeptide 1B3
Core Tip	Experiments with Oatp1a/1b-null mice and Oatp1a/1b; Abcc3 combination knockout mice plainly demonstrated that even under physiologic conditions a substantial portion of bilirubin glucuronides is not excreted directly into bile but is transported back to the blood by Abcc3. Oatp1a/1b activity accentuated in downstream (centrizonal) hepatocytes allows efficient reuptake of bilirubin conjugates, with a subsequent possibility being safely eliminated by excretion into bile. This and molecular findings in Rotor syndrome suggest that human transporters MRP3 and OATP1Bs form a sinusoidal liver-to-blood cycle which mediates shifting (hopping) of bilirubin and other substrates from periportal to centrizonal hepatocytes (References 18, 19, 22, 125).
Publish Date	2013-10-15 17:26
Citation	Sticova E, Jirsa M. New insights in bilirubin metabolism and their clinical implications. World J Gastroenterol 2013; 19(38): 6398-6407
URL	http://www.wjgnet.com/1007-9327/full/v19/i38/6398.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i38.6398

Full Article (PDF)	WJG-19-6398.pdf
Manuscript File	3411-Review.docx
Answering Reviewers	3411-Answering reviewers.pdf
Copyright License Agreement	3411-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	3411-Language certificate.pdf
Peer-review Report	3411-Peer review(s).pdf
Scientific Editor Work List	3411-Scientific editor work list.doc