| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun Li, Rui Zhou, Bei-Bei Bie, Na Huang, Ying Guo, Hai-Yan Chen, Meng-Jiao Shi, Jun Yang, Jian zhang and Zong-Fang Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
30901945 |
| Science Research Foundation of Shaanxi Administration of Traditional Chinese Medicine |
15-ZY029 |
| Science Research Foundation of the Second Affiliated Hospital of Xi’an Jiaotong University |
RC(XM)201602 |
|
| Corresponding Author |
Zong-Fang Li, MD, PhD, Chief Doctor, Professor, National & Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi’an Jiaotong University, 157 West 5th Road, Xi’an 710004, Shaanxi Province, China. lzf2568@xjtu.edu.cn |
| Key Words |
inositol (1,4,5)-trisphosphate receptor; Severe acute pancreatitis; Calcium overload; Emodin; Baicalein; Pancreatic acinar cell |
| Core Tip |
combined use of emodin and baicalein (CEB) was found to act on key aspects of severe acute pancreatitis (SAP) pathogenesis; it regulated inflammatory factors and inhibited calcium overload, which underlie this synergy. These results at the cellular and organism levels reflect a preliminary mechanism of CEB in SAP and indicate that the development of CEB is promising for the treatment of patients with SAP. |
| Publish Date |
2018-01-07 04:21 |
| Citation |
Li J, Zhou R, Bie BB, Huang N, Guo Y, Chen HY, Shi MJ, Yang J, Zhang J, Li ZF. Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells. World J Gastroenterol 2018; 24(1): 35-45 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i1/35.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i1.35 |
