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10/12/2018 5:32:21 AM | Browse: 211 | Download: 117
Publication Name World Journal of Gastroenterology
Manuscript ID 41156
Country of Manuscript Source Germany
Received
2018-08-01 01:06
Peer-Review Started
2018-08-01 01:19
To Make the First Decision
2018-08-27 01:52
Return for Revision
2018-08-27 07:18
Revised
2018-09-20 09:38
Second Decision
2018-09-27 06:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-05 23:05
Articles in Press
2018-10-05 23:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-10-10 01:53
Publish the Manuscript Online
2018-10-12 05:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia
Manuscript Source Invited Manuscript
All Author List Franziska J Ammon, Anna Kohlhaas, Omar Elshaarawy, Johannes Mueller, Thomas Bruckner, Christof Sohn, Gabriele Fluhr, Herbert Fluhr and Sebastian Mueller
ORCID
Author(s) ORCID Number
Franziska J Ammon http://orcid.org/0000-0002-8877-9711
Anna Kohlhaas http://orcid.org/0000-0001-7677-1619
Omar Elshaarawy http://orcid.org/0000-0002-6945-6204
Johannes Mueller http://orcid.org/0000-0002-5205-4129
Thomas Bruckner http://orcid.org/0000-0001-9342-3456
Christof Sohn http://orcid.org/0000-0001-9430-4037
Gabriele Fluhr http://orcid.org/0000-0001-7415-2312
Herbert Fluhr http://orcid.org/0000-0001-9300-4868
Sebastian Mueller http://orcid.org/0000-0002-3577-8491
Funding Agency and Grant Number
Funding Agency Grant Number
DFG MU 1373/9-1
Corresponding author Sebastian Mueller, MD, PhD, Professor, Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center and Center for Alcohol Research and Liver Disease, University of Heidelberg, Zeppelinstraße 11–33, Heidelberg 69121, Germany. sebastian.mueller@urz.uni-heidelberg.de
Keywords Pregnancy; Transient elastography; Liver stiffness; Pregnancy complications; Hemolysis, elevated liver enzymes and low platelets syndrome; Intrahepatic cholestasis of pregnancy; Preeclampsia
Core Tip Liver stiffness (LS) was measured by transient elastography during pregnancy in 537 healthy pregnant women without complications and in 62 women with pregnancy complications such as preeclampsia or intrahepatic cholestasis of pregnancy. Our results show that LS increases during pregnancy to levels above 6 kPa even in women without pregnancy complications and rapidly normalizes within 24 h after delivery. LS was significantly elevated in women with preeclampsia and, moreover, an independent predictor for preeclampsia in multivariate analysis. In conclusion, LS could be a novel non-invasive screening parameter to identify pregnant women at risk for complications of pregnancy.
Publish Date 2018-10-12 05:32
Citation Ammon FJ, Kohlhaas A, Elshaarawy O, Mueller J, Bruckner T, Sohn C, Fluhr G, Fluhr H, Mueller S. Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia. World J Gastroenterol 2018; 24(38): 4393-4402
Url http://www.wjgnet.com/1007-9327/full/v24/i38/4393.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i38.4393
Full Article (PDF) WJG-24-4393.pdf
Manuscript File 41156-Review.docx
Answering Reviewers 41156-Answering reviewers.pdf
Audio Core Tip 41156-Audio core tip.mp3
Biostatistics Review Certificate 41156-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 41156-Conflict-of-interest statement.pdf
Copyright License Agreement 41156-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41156-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 41156-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 41156-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 41156-Non-Native-Speakers-of-English-Editing-Certificate-revision.pdf
Supplementary Material 41156-Supplementary material.pdf
Peer-review Report 41156-Peer-review(s).pdf
Scientific Misconduct Check 41156-Scientific misconduct check.pdf
Scientific Editor Work List 41156-Scientific editor work list.pdf