| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Franziska J Ammon, Anna Kohlhaas, Omar Elshaarawy, Johannes Mueller, Thomas Bruckner, Christof Sohn, Gabriele Fluhr, Herbert Fluhr and Sebastian Mueller |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| DFG |
MU 1373/9-1 |
|
| Corresponding Author |
Sebastian Mueller, MD, PhD, Professor, Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center and Center for Alcohol Research and Liver Disease, University of Heidelberg, Zeppelinstraße 11–33, Heidelberg 69121, Germany. sebastian.mueller@urz.uni-heidelberg.de |
| Key Words |
Pregnancy; Transient elastography; Liver stiffness; Pregnancy complications; Hemolysis, elevated liver enzymes and low platelets syndrome; Intrahepatic cholestasis of pregnancy; Preeclampsia |
| Core Tip |
Liver stiffness (LS) was measured by transient elastography during pregnancy in 537 healthy pregnant women without complications and in 62 women with pregnancy complications such as preeclampsia or intrahepatic cholestasis of pregnancy. Our results show that LS increases during pregnancy to levels above 6 kPa even in women without pregnancy complications and rapidly normalizes within 24 h after delivery. LS was significantly elevated in women with preeclampsia and, moreover, an independent predictor for preeclampsia in multivariate analysis. In conclusion, LS could be a novel non-invasive screening parameter to identify pregnant women at risk for complications of pregnancy. |
| Publish Date |
2018-10-12 05:32 |
| Citation |
Ammon FJ, Kohlhaas A, Elshaarawy O, Mueller J, Bruckner T, Sohn C, Fluhr G, Fluhr H, Mueller S. Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia. World J Gastroenterol 2018; 24(38): 4393-4402 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i38/4393.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i38.4393 |
