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1/21/2019 5:38:30 AM | Browse: 917 | Download: 1143
Publication Name World Journal of Gastroenterology
Manuscript ID 42991
Country/Territory South Korea
Received
2018-10-18 03:48
Peer-Review Started
2018-10-18 07:51
To Make the First Decision
2018-11-29 09:16
Return for Revision
2018-11-30 03:35
Revised
2018-12-21 02:28
Second Decision
2018-12-21 09:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-21 22:01
Articles in Press
2018-12-21 22:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-01-17 07:06
Publish the Manuscript Online
2019-01-21 05:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production
Manuscript Source Unsolicited Manuscript
All Author List Jung Hwan Yoon, Yeon Soo Lee, Olga Kim, Hassan Ashktorab, Duane T Smoot, Suk Woo Nam and Won Sang Park
ORCID
Author(s) ORCID Number
Jung Hwan Yoon http://orcid.org/0000-0001-7770-2965
Yeon Soo Lee http://orcid.org/0000-0002-1653-6315
Olga Kim http://orcid.org/0000-0001-5110-2523
Hassan Ashktorab http://orcid.org/0000-0002-4048-4666
Duane T Smoot http://orcid.org/0000-0002-8416-7419
Suk Woo Nam http://orcid.org/0000-0001-5767-8291
Won Sang Park http://orcid.org/0000-0002-9090-0584
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Foundation of Korea 2018R1A2A2A14019713
Corresponding Author Won Sang Park, MD, PhD, Doctor, Professor, Department of Pathology, College of Medicine, The Catholic University of Korea, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, Korea. wonsang@catholic.ac.kr., Seoul 137-701, South Korea. wonsang@catholic.ac.kr
Key Words NKX6.3; Gastric mucosa; Atrophy; Amyloid β; Gastrokine 1
Core Tip In human gastric epithelial cells, NKX6.3 depletion induced production of amyloid β (Aβ) oligomers, and also increased expression of apolipoprotein E (ApoE), Aβ, β-secretase 1 (Bace1), nicastrin, and receptor for advanced glycosylation end product proteins. Moreover, NKX6.3 depletion leads to stably formed of γ-secretase complex and binding to Bace1 protein. In gastric mucosae with atrophy, expression of Aβ oligomer, ApoE, and Bace1 was detected and inversely correlated with NKX6.3 expression. Additionally, treatment with recombinant Aβ 1-42 produced oligomeric forms of Aβ and significantly decreased cell viability in NKX6.3 depleting cells. These observations provide evidences that NKX6.3 can inhibit gastric mucosal atrophy by regulating Aβ peptide accumulation and inflammatory reaction in gastric epithelial cells.
Publish Date 2019-01-21 05:38
Citation Yoon JH, Lee YS, Kim O, Ashktorab H, Smoot DT, Nam SW, Park WS. NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production. World J Gastroenterol 2019; 25(3): 330-345
URL https://www.wjgnet.com/1007-9327/full/v25/i3/330.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i3.330
Full Article (PDF) WJG-25-330.pdf
Full Article (Word) WJG-25-330.docx
Manuscript File 42991-Review.docx
Answering Reviewers 42991-Answering reviewers.pdf
Audio Core Tip 42991-Audio core tip.mp3
Biostatistics Review Certificate 42991-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42991-Conflict-of-interest statement.pdf
Copyright License Agreement 42991-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42991-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 42991-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 42991-Language certificate.pdf
Supplementary Material 42991-Supplementary material.pdf
Peer-review Report 42991-Peer-review(s).pdf
Scientific Misconduct Check 42991-Scientific misconduct check.pdf
Scientific Editor Work List 42991-Scientific editor work list.pdf