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4/26/2019 3:39:24 AM | Browse: 565 | Download: 533
Publication Name World Journal of Hepatology
Manuscript ID 44797
Country/Territory Argentina
2018-11-28 01:22
Peer-Review Started
2018-11-28 05:50
To Make the First Decision
2019-01-30 03:27
Return for Revision
2019-02-12 07:25
2019-02-21 14:45
Second Decision
2019-03-22 08:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-25 04:54
Articles in Press
2019-03-25 04:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-04-24 05:55
Publish the Manuscript Online
2019-04-26 03:39
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title MicroRNAs contribute to ATP-binding cassette transporter- and autophagy-mediated chemoresistance in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Maria V Espelt, Maria L Bacigalupo, Pablo Carabias and Maria F Troncoso
Author(s) ORCID Number
Maria V Espelt http://orcid.org/0000-0002-0388-7853
Maria L Bacigalupo http://orcid.org/0000-0003-4114-2622
Pablo Carabias http://orcid.org/0000-0002-2709-9165
Maria F Troncoso http://orcid.org/0000-0002-4919-9976
Funding Agency and Grant Number
Corresponding Author Maria F Troncoso, PhD, Academic Research, Research Assistant Professor, Facultad de Farmacia y Bioquímica, Instituto de Química y Fisicoquímica Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Junín 956, Buenos Aires C1113AAD, Argentina. ma.f.troncoso@gmail.com
Key Words Hepatocellular carcinoma; Chemoresistance; ABC transporter; Autophagy; miRNA
Core Tip The main obstacle during treatment of hepatocellular carcinoma (HCC) is resistance to chemotherapy. We analyzed microRNAs (miRNAs) impact on HCC chemoresistance. Certain miRNAs target ABC transporter genes. As most of these miRNAs are downregulated in HCC, transporter levels increase and intracellular drug accumulation decrease, turning cells less sensitive to death. Others miRNAs target autophagy-related gene expression, inhibiting autophagy and acting as tumor suppressors. Nevertheless, due to its downregulation in HCC, these miRNAs do not inhibit autophagy or tumor growth and, resistance is favored. ABC transporter and/or autophagy-related gene expression modulated by miRNAs affect HCC cell survival under chemotherapy.
Publish Date 2019-04-26 03:39
Citation Espelt MV, Bacigalupo ML, Carabias P, Troncoso MF. MicroRNAs contribute to ATP-binding cassette transporter- and autophagy-mediated chemoresistance in hepatocellular carcinoma. World J Hepatol 2019; 11(4): 344-358
URL https://www.wjgnet.com/1948-5182/full/v11/i4/344.htm
DOI https://dx.doi.org/10.4254/wjh.v11.i4.344
Full Article (PDF) WJH-11-344.pdf
Full Article (Word) WJH-11-344.docx
Manuscript File 44797-Review.docx
Answering Reviewers 44797-Answering reviewers.pdf
Audio Core Tip 44797-Audio core tip.wav
Conflict-of-Interest Disclosure Form 44797-Conflict-of-interest statement.pdf
Copyright License Agreement 44797-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 44797-Grant application form(s).pdf
Peer-review Report 44797-Peer-review(s).pdf
Scientific Misconduct Check 44797-Scientific misconduct check.pdf
Scientific Editor Work List 44797-Scientific editor work list.pdf