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7/28/2020 2:46:56 PM | Browse: 19 | Download: 14
Publication Name World Journal of Gastroenterology
Manuscript ID 56453
Country/Territory Poland
Received
2020-04-30 17:58
Peer-Review Started
2020-04-30 17:59
To Make the First Decision
Return for Revision
2020-05-15 21:32
Revised
2020-05-26 13:51
Second Decision
2020-07-16 09:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-07-16 23:43
Articles in Press
2020-07-16 23:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-07-27 00:32
Publish the Manuscript Online
2020-07-28 14:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression
Manuscript Source Unsolicited Manuscript
All Author List Karolina Lomperta, Katarzyna Jakubowska, Malgorzata Grudzinska, Luiza Kanczuga-Koda, Andrzej Wincewicz, Eva Surmacz, Stanislaw Sulkowski and Mariusz Koda
ORCID
Author(s) ORCID Number
Karolina Lomperta http://orcid.org/0000-0002-2643-6529
Katarzyna Jakubowska http://orcid.org/0000-0002-4960-7204
Malgorzata Grudzinska http://orcid.org/0000-0002-1809-2383
Luiza Kanczuga-Koda http://orcid.org/0000-0001-6261-2596
Andrzej Wincewicz http://orcid.org/0000-0003-0836-2199
Eva Surmacz http://orcid.org/0000-0002-2285-7529
Stanislaw Sulkowski http://orcid.org/0000-0003-3943-8467
Mariusz Koda http://orcid.org/0000-0002-1678-567X
Funding Agency and Grant Number
Corresponding author Karolina Lomperta, MD, Doctor, Department of General Pathomorphology, Medical University of Bialystok, 13 Waszyngtona Street, Bialystok 15269, Poland. karlomperta@gmail.com
Keywords Colorectal cancer; Insulin receptor substrate-1; Bax protein; Bcl-xL protein; Apoptosis; Antigen Ki-67
Core Tip We analyzed the expressions of Insulin receptor substrate 1 (IRS-1), Bax, Bcl-xL and Ki-67 proteins in primary colorectal cancer (CRC). We found that IRS-1 expression was associated with tumor grade and histological type, and was more prevalent in more differentiated CRC. Interestingly, IRS-1 expression was significantly correlated with Bax and Bcl-xL, but not with Ki-67. We hypothesize that coexpression of IRS-1 and proapoptotic and antiapoptotic markers could result in a complex and diverse interplay characteristic for earlier stages in CRC.
Publish Date 2020-07-28 14:46
Citation Lomperta K, Jakubowska K, Grudzinska M, Kanczuga-Koda L, Wincewicz A, Surmacz E, Sulkowski S, Koda M. Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression. World J Gastroenterol 2020; 26(28): 4140-4150
Url https://www.wjgnet.com/1007-9327/full/v26/i28/4140.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i28.4140
Full Article (PDF) WJG-26-4140.pdf
Full Article (Word) WJG-26-4140.docx
Manuscript File 56453-Review.docx
Answering Reviewers 56453-Answering reviewers.pdf
Audio Core Tip 56453-Audio core tip.mp3
Biostatistics Review Certificate 56453-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 56453-Conflict-of-interest statement.pdf
Copyright License Agreement 56453-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 56453-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 56453-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 56453-Language certificate.pdf
Peer-review Report 56453-Peer-review(s).pdf
Scientific Misconduct Check 56453-Bing-Yan JP-1.png
Scientific Misconduct Check 56453-Scientific misconduct check.pdf
Scientific Editor Work List 56453-Scientific editor work list.pdf