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3/1/2021 3:51:08 AM | Browse: 179 | Download: 521
Publication Name World Journal of Clinical Cases
Manuscript ID 60185
Country/Territory China
2020-10-23 12:19
Peer-Review Started
2020-10-23 12:19
To Make the First Decision
Return for Revision
2020-11-20 07:41
2020-12-24 16:40
Second Decision
2021-01-07 12:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-01-07 17:49
Articles in Press
2021-01-07 17:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-01-21 00:07
Typeset the Manuscript
2021-02-24 06:15
Publish the Manuscript Online
2021-03-01 03:51
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Case Report
Article Title Human menstrual-blood-derived stem cells as immunoregulatory therapy in COVID-19: A case report and review of literature
Manuscript Source Unsolicited Manuscript
All Author List Juan Lu, Zhong-Yang Xie, Dan-Hua Zhu and Lan-Juan Li
Author(s) ORCID Number
Juan Lu http://orcid.org/0000-0002-5508-0410
Zhong-Yang Xie http://orcid.org/0000-0003-0551-5137
Dan-Hua Zhu http://orcid.org/0000-0001-8940-0681
Lan-Juan Li http://orcid.org/0000-0001-6945-0593
Funding Agency and Grant Number
Corresponding Author Lan-Juan Li, FAASLD, Attending Doctor, Chairman, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qing-chun Road, Hangzhou 310003, Zhejiang, China. ljli@zju.edu.cn
Key Words COVID-19; Human menstrual-blood-derived stem cells; Immunoregulatory therapy; Inflammatory response; Cytokine storm; Case report
Core Tip The coronavirus disease 2019 (COVID-19) is the word that certainly isn’t forgotten by everybody who lives in the first half of the twenty-first century.It has led many researchers from different biomedical fields to find solutions or treatments to manage the pandemic. However, there is still no current effective guidance for the clinical management of COVID-19. Mesenchymal stem cells are widely used to treat tissue and organ injuries with effective immunomodulatory and repair capacities, which makes them ideal for allogenic adoptive transfer therapy. In this study, we describe the first confirmed case of COVID-19 in Hangzhou, China to explore the role of human menstrual blood-derived stem cells (MenSCs) in the treatment of COVID-19. Moreover, we review the immunomodulation effect including non-specific and specific immune functions of MenSCs for the therapy of COVID-19, which can be helpful to find a promisingly therapeutic approach for this disease.
Publish Date 2021-03-01 03:51
Citation Lu J, Xie ZY, Zhu DH, Li LJ. Human menstrual-blood-derived stem cells as immunoregulatory therapy in COVID-19: A case report and review of literature. World J Clin Cases 2021; 9(7): 1705-1713
URL https://www.wjgnet.com/2307-8960/full/v9/i7/1705.htm
DOI https://dx.doi.org/10.12998/wjcc.v9.i7.1705
Full Article (PDF) WJCC-9-1705.pdf
Full Article (Word) WJCC-9-1705.docx
Manuscript File 60185_Auto_Edited_WangTQ.docx
Answering Reviewers 60185-Answering reviewers.pdf
Audio Core Tip 60185-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 60185-Conflict-of-interest statement.pdf
Copyright License Agreement 60185-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 60185-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 60185-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 60185-Language certificate.pdf
Supplementary Material 60185-Supplementary material.pdf
Peer-review Report 60185-Peer-review(s).pdf
Scientific Misconduct Check 60185-Bing-Gao CC-1.jpg
Scientific Misconduct Check 60185-Bing-Liu M-2.png
Scientific Misconduct Check 60185-Scientific misconduct check.pdf
Scientific Editor Work List 60185-Scientific editor work list.pdf