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4/2/2021 12:29:13 PM | Browse: 35 | Download: 124
Publication Name World Journal of Clinical Cases
Manuscript ID 61472
Country/Territory Taiwan
2020-12-12 15:47
Peer-Review Started
2020-12-12 15:50
To Make the First Decision
Return for Revision
2020-12-18 13:07
2021-01-01 04:45
Second Decision
2021-02-22 13:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-02-22 19:44
Articles in Press
2021-02-22 19:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-03-01 14:16
Typeset the Manuscript
2021-03-29 12:58
Publish the Manuscript Online
2021-04-02 12:29
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Case Report
Article Title Combined immune checkpoint inhibitors of CTLA4 and PD-1 for hepatic melanoma of unknown primary origin: A case report
Manuscript Source Unsolicited Manuscript
All Author List An-Che Cheng, Yi-Jia Lin, Sung-Hua Chiu and Yu-Lueng Shih
Author(s) ORCID Number
An-Che Cheng http://orcid.org/0000-0002-2312-6613
Yi-Jia Lin http://orcid.org/0000-0002-8073-8659
Sung-Hua Chiu http://orcid.org/0000-0003-1118-5541
Yu-Lueng Shih http://orcid.org/0000-0003-4629-4393
Funding Agency and Grant Number
Corresponding Author Yu-Lueng Shih, PhD, Academic Research, Associate Professor, Attending Doctor, Department of Internal Medicine, Division of Gastroenterology, Tri-Service General Hospital, National Defense Medical Center, No 325, Section 2, Cheng-Kung Road, Neihu, Taipei 114, Taiwan. albreb@ms28.hinet.net
Key Words Metastatic melanoma with unknown primary; Liver metastasis; Immune checkpoint inhibitor; Programmed death protein-1; Cytotoxic T-lymphocyte-associated antigen 4; Case report
Core Tip Hepatic metastatic melanoma with an unknown primary site (MUP) is extremely rare and there is limited information on the pathogenesis, clinical and imaging features, pathological findings and treatment outcome. There are no guidelines for the use of immune checkpoint inhibitors (ICIs) in hepatic MUP. We report the first case of hepatic MUP treated by ICIs with combined cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed death protein-1 (PD-1), describing the clinical features, imaging, pathological findings, and outcome. This case showed better treatment outcome than previous cases of hepatic MUP. ICIs combined with PD-1 and CTLA-4 may be considered as the first‐line therapy for patients with hepatic MUP.
Publish Date 2021-04-02 12:29
Citation Cheng AC, Lin YJ, Chiu SH, Shih YL. Combined immune checkpoint inhibitors of CTLA4 and PD-1 for hepatic melanoma of unknown primary origin: A case report. World J Clin Cases 2021; 9(11): 2641-2648
URL https://www.wjgnet.com/2307-8960/full/v9/i11/2641.htm
DOI https://dx.doi.org/10.12998/wjcc.v9.i11.2641
Full Article (PDF) WJCC-9-2641.pdf
Full Article (Word) WJCC-9-2641.docx
Manuscript File 61472_Auto_Edited_LM_WangTQ.docx
Answering Reviewers 61472-Answering reviewers.pdf
Audio Core Tip 61472-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 61472-Conflict-of-interest statement.pdf
Copyright License Agreement 61472-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 61472-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 61472-Language certificate.pdf
Peer-review Report 61472-Peer-review(s).pdf
Scientific Misconduct Check 61472-Bing-Zhang L-1.png
Scientific Misconduct Check 61472-Bing-Liu M-2.png
Scientific Misconduct Check 61472-Scientific misconduct check.pdf
Scientific Editor Work List 61472-Scientific editor work list.pdf