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10/13/2021 12:57:54 PM | Browse: 15 | Download: 12
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 64684
Country/Territory China
Received
2021-02-22 11:51
Peer-Review Started
2021-02-22 11:51
To Make the First Decision
Return for Revision
2021-06-04 03:34
Revised
2021-06-11 07:45
Second Decision
2021-07-22 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-07-23 05:19
Articles in Press
2021-07-23 05:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-08-17 03:43
Typeset the Manuscript
2021-10-08 02:13
Publish the Manuscript Online
2021-10-13 12:57
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Proliferation cell nuclear antigen clamp associated factor, a potential proto-oncogene with increased expression in malignant gastrointestinal tumors
Manuscript Source Invited Manuscript
All Author List Li-Juan Liu, Jian-Ming Liao and Fan Zhu
ORCID
Author(s) ORCID Number
Li-Juan Liu http://orcid.org/0000-0002-2549-5463
Jian-Ming Liao http://orcid.org/0000-0002-6196-0510
Fan Zhu http://orcid.org/0000-0001-7031-2956
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81971943
National Natural Science Foundation of China 81772196
Hubei Provincial Natural Science Foundation of China 2020CFB656
Corresponding Author Fan Zhu, PhD, Professor, State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy & Immunology, Department of Medical Microbiology, School of Medicine, Wuhan University, No. 185 Donghu Rd, Wuhan 430071, Hubei , China. fanzhu@whu.edu.cn
Key Words Proliferation cell nuclear antigen; Proliferation cell nuclear antigen clamp associated factor; Transcript variant; Gastrointestinal cancers; Signal pathway; Biological therapeutic
Core Tip In interaction with proliferation cell nuclear antigen (PCNA), PCNA clamp associated factor (PCLAF) plays a crucial role in cell proliferation, DNA repair, and cell cycle regulation. PCLAF shows a causal relationship with gastrointestinal (GI) cancers as PCLAF highly expresses in GI tumors and predicts poor progression. PCLAF also associates with numerous other malignancies and autoimmune diseases. This review discusses the role of PCLAF in GI cancers, as well as the underlying molecular mechanism. Biological therapeutics by targeting PCLAF in cancers are also included.
Publish Date 2021-10-13 12:57
Citation Liu LJ, Liao JM, Zhu F. Proliferating cell nuclear antigen clamp associated factor, a potential proto-oncogene with increased expression in malignant gastrointestinal tumors. World J Gastrointest Oncol 2021; 13(10): 1425-1439
URL https://www.wjgnet.com/1948-5204/full/v13/i10/1425.htm
DOI https://dx.doi.org/10.4251/wjgo.v13.i10.1425
Full Article (PDF) WJGO-13-1425.pdf
Full Article (Word) WJGO-13-1425.docx
Manuscript File 64684_Auto_Edited-JPY-Webster J-revised[24335]-Clear.docx
Answering Reviewers 64684-Answering reviewers.pdf
Audio Core Tip 64684-Audio core tip.mp4
Conflict-of-Interest Disclosure Form 64684-Conflict-of-interest statement.pdf
Copyright License Agreement 64684-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 64684-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 64684-Language certificate.pdf
Peer-review Report 64684-Peer-review(s).pdf
Scientific Misconduct Check 64684-Scientific misconduct check.pdf
Scientific Editor Work List 64684-Scientific editor work list.pdf