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10/15/2021 9:56:18 AM | Browse: 223 | Download: 333
Publication Name World Journal of Psychiatry
Manuscript ID 67829
Country/Territory Canada
2021-05-03 12:38
Peer-Review Started
2021-05-03 12:41
To Make the First Decision
Return for Revision
2021-06-17 04:51
2021-06-27 16:13
Second Decision
2021-09-02 02:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-02 05:19
Articles in Press
2021-09-02 05:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-10-13 06:50
Publish the Manuscript Online
2021-10-15 09:56
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Frontier
Article Title Framework for internal sensation of pleasure using constraints from disparate findings in nucleus accumbens
Manuscript Source Invited Manuscript
All Author List Kunjumon Ittira Vadakkan
Author(s) ORCID Number
Kunjumon Ittira Vadakkan http://orcid.org/0000-0002-2721-6931
Funding Agency and Grant Number
Corresponding Author Kunjumon Ittira Vadakkan, MBBS, MD, MSc, PhD, Senior Scientist, Division of Neuroscience, Neurosearch Center, 167 Brunswick Street, Toronto M5S2M3, Ontario, Canada. kunjumon.vadakkan@utoronto.ca
Key Words Pleasure; Internal sensation; Mind; Memory; Long-term potentiation; Long-term depression; Nucleus accumbens; Drug addiction
Core Tip Pleasure has been studied by examining animal behaviour and its correlations with molecular and electrophysiological changes. Drugs of abuse generate pleasure along with several seemingly unrelated changes in nucleus accumbens (NAc). When pleasure was examined as a first-person inner sensation, it was possible to arrive at a framework of a causal mechanism for its generation that can also provide inter-connected mechanistic explanations for long-term depression (LTD) in NAc in naïve animals, impaired ability to induce LTD in addicted state, attenuation of postsynaptic potentials by both cocaine and dopamine, and reduced firing of medium spiny neurons in NAc by dopamine. Findings made by this work are testable.
Publish Date 2021-10-15 09:56
Citation Vadakkan KI. Framework for internal sensation of pleasure using constraints from disparate findings in nucleus accumbens. World J Psychiatr 2021; 11(10): 681-695
URL https://www.wjgnet.com/2220-3206/full/v11/i10/681.htm
DOI https://dx.doi.org/10.5498/wjp.v11.i10.681
Full Article (PDF) WJP-11-681.pdf
Full Article (Word) WJP-11-681.docx
Manuscript File 67829_Auto_Edited-JPY.docx
Answering Reviewers 67829-Answering reviewers.pdf
Audio Core Tip 67829-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 67829-Conflict-of-interest statement.pdf
Copyright License Agreement 67829-Copyright license agreement.pdf
Peer-review Report 67829-Peer-review(s).pdf
Scientific Misconduct Check 67829-Bing-Fan JR-2.png
Scientific Misconduct Check 67829-Scientific misconduct check.pdf
Scientific Editor Work List 67829-Scientific editor work list.pdf