Publication Name	World Journal of Clinical Cases
Manuscript ID	71163
Country	China

Received	2021-08-29 15:08
Peer-Review Started	2021-08-29 15:09
To Make the First Decision
Return for Revision	2021-11-17 00:58
Revised	2021-11-25 16:06
Second Decision	2022-01-10 05:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-10 22:14
Articles in Press	2022-01-10 22:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-06 20:39
Typeset the Manuscript	2022-01-13 04:03
Publish the Manuscript Online	2022-02-23 15:51

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Novel ABCB4 mutations in an infertile female with progressive familial intrahepatic cholestasis type 3: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Tian-Fu Liu, Jing-Jing He, Liang Wang and Ling-Yi Zhang
ORCID	Author(s) ORCID Number Tian-Fu Liu http://orcid.org/0000-0002-6909-5197 Jing-Jing He http://orcid.org/0000-0002-1057-6375 Liang Wang http://orcid.org/0000-0003-1620-7682 Ling-Yi Zhang http://orcid.org/0000-0002-0434-7533
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Gansu Province 21JR7RA410
Corresponding Author	Ling-Yi Zhang, MD, Professor, Department of Hepatology, Lanzhou University Second Hospital, No. 82 Cuiyingmen, Chengguan District, Lanzhou 730030, Gansu Province, China. zhanglymd@126.com
Key Words	Progressive familial intrahepatic cholestasis type 3; ABCB4 gene; Infertility; Intrahepatic cholestasis of pregnancy; Case report
Core Tip	This is the first case report of an adult patient with progressive familial intrahepatic cholestasis type 3 (PFIC3) and infertility. Gene detection was central to making a definitive diagnosis. The novel ABCB4 heterozygous mutations observed exhibited a variety of clinical phenotypes. A genetic predisposition to infertility may also be present in this patient and requires further research. The discovery of these new mutations has enriched the information on the clinical features of PFIC3 and contributed to a more comprehensive understanding of ABCB4 disease.
Publish Date	2022-02-23 15:51
Citation	Liu TF, He JJ, Wang L, Zhang LY. Novel ABCB4 mutations in an infertile female patient with progressive familial intrahepatic cholestasis type 3: A case report. World J Clin Cases 2022; 10(6): 1998-2006
URL	https://www.wjgnet.com/2307-8960/full/v10/i6/1998.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i6.1998

Full Article (PDF)	WJCC-10-1998.pdf
Full Article (Word)	WJCC-10-1998.docx
CARE Checklist–2016	71163-CARE-Checklist–2016-revision.pdf
Manuscript File	71163_Auto_Edited-YJM-Webster JR.docx
Answering Reviewers	71163-Answering reviewers.pdf
Audio Core Tip	71163-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	71163-Conflict-of-interest statement.pdf
Copyright License Agreement	71163-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	71163-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	71163-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	71163-Language certificate.pdf
Peer-review Report	71163-Peer-review(s).pdf
Scientific Misconduct Check	71163-Bing-Ma YJ-2.png
Scientific Editor Work List	71163-Scientific editor work list.pdf