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8/3/2022 9:47:21 AM | Browse: 16 | Download: 32
Publication Name World Journal of Translational Medicine
Manuscript ID 76831
Country/Territory India
2022-04-02 17:49
Peer-Review Started
2022-04-02 17:50
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Return for Revision
2022-05-31 02:52
2022-06-14 02:25
Second Decision
2022-07-13 02:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-07-17 23:52
Articles in Press
2022-07-17 23:52
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Edit the Manuscript by Language Editor
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2022-07-31 23:55
Publish the Manuscript Online
2022-08-03 09:47
ISSN 2220-6132 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Clinical Neurology
Manuscript Type Basic Study
Article Title Cell-free mitochondrial DNA quantification in ischemic stroke patients for non-invasive and real-time monitoring of disease status
Manuscript Source Unsolicited Manuscript
All Author List Nusrath Fathima, Sandhya Manorenj, Sandeep Kumar Vishwakarma and Aleem Ahmed Khan
Author(s) ORCID Number
Nusrath Fathima http://orcid.org/0000-0001-9802-0146
Sandhya Manorenj http://orcid.org/0000-0003-4699-3645
Sandeep Kumar Vishwakarma http://orcid.org/0000-0001-5731-8210
Aleem Ahmed Khan http://orcid.org/0000-0001-7075-9037
Funding Agency and Grant Number
Corresponding Author Aleem Ahmed Khan, PhD, Senior Scientist, Central Laboratory for Stem Cell Research and Translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad 500058, Telangana, India. aleem_a_khan@rediffmail.com
Key Words Cell-free mitochondrial DNA; NADH-ubiquinone oxidoreductase chain 1; Ischemic stroke; Circulating biomarker; National Institute of Health Stroke Scale score; Stroke assessment; Severity and outcome
Core Tip Several blood biomarkers have been studied to determine the severity and outcome of ischemic stroke with limited applications. Hence, we need to establish molecular markers which can provide more comprehensive information on the stroke pathophysiology and treatment response. Dynamic quantification of plasma cell-free DNA appears to be a valid and reliable option. Hence, we compared the real-time expression of cell-free mitochondrial DNA (NADH-ubiquinone oxidoreductase chain 1 gene) in ischemic stroke patients with healthy controls and studies its prognostic value during the treatment. This study could aid in the development of clinical values for assessing real-time, non-invasive mode of ischemic stroke status in the future.
Publish Date 2022-08-03 09:47
Citation Fathima N, Manorenj S, Vishwakarma SK, Khan AA. Cell-free mitochondrial DNA quantification in ischemic stroke patients for non-invasive and real-time monitoring of disease severity and outcome. World J Transl Med 2022; 10(2):14-28
URL https://www.wjgnet.com/2220-3230/full/v10/i2/14.htm
DOI https://dx.doi.org/10.5528/wjtm.v10.i2.14
Full Article (PDF) WJTM-10-14.pdf
Full Article (Word) WJTM-10-14.docx
Manuscript File 76831_Auto_Edited-LS.docx
Answering Reviewers 76831-Answering reviewers.pdf
Audio Core Tip 76831-Audio core tip.m4a
Biostatistics Review Certificate 76831-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 76831-Conflict-of-interest statement.pdf
Copyright License Agreement 76831-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 76831-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 76831-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 76831-Language certificate.pdf
Peer-review Report 76831-Peer-review(s).pdf
Scientific Misconduct Check 76831-Bing-Wang LL-2.png
Scientific Editor Work List 76831-Scientific editor work list.pdf