Publication Name	World Journal of Diabetes
Manuscript ID	78491
Country	Hungary

Received	2022-07-05 13:22
Peer-Review Started	2022-07-05 13:33
To Make the First Decision
Return for Revision	2022-08-03 05:34
Revised	2022-08-16 20:07
Second Decision	2022-10-24 03:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-10-28 18:24
Articles in Press	2022-10-28 18:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-11-17 08:53
Typeset the Manuscript	2023-01-05 13:25
Publish the Manuscript Online	2023-01-10 08:58

ISSN	1948-9358 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Gut region-specific TNFR expression: TNFR2 is more affected than TNFR1 in duodenal myenteric ganglia of diabetic rats
Manuscript Source	Unsolicited Manuscript
All Author List	Bence Pál Barta, Benita Onhausz, Afnan AL Doghmi, Zita Szalai, János Balázs, Mária Bagyánszki and Nikolett Bódi
ORCID	Author(s) ORCID Number Bence Pál Barta http://orcid.org/0000-0002-5309-8633 Benita Onhausz http://orcid.org/0000-0002-6043-5968 Afnan AL Doghmi http://orcid.org/0000-0003-3242-9859 Zita Szalai http://orcid.org/0000-0002-8722-0211 János Balázs http://orcid.org/0000-0003-1775-6915 Mária Bagyánszki http://orcid.org/0000-0003-3533-9461 Nikolett Bódi http://orcid.org/0000-0002-9774-1387
Funding Agency and Grant Number	Funding Agency Grant Number Hungarian National Research, Development and Innovation Fund projects GINOP-2.3.3-15-2016-00006 Hungarian NKFIH Fund Project FK131789 János Bolyai Research Scholarship of the Hungarian Academy of Sciences ÚNKP-21-5 - New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund Gedeon Richter Plc Centenary Foundation
Corresponding Author	Mária Bagyánszki, PhD, Associate Professor, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged 6726, Hungary. bmarcsi@bio.u-szeged.hu
Key Words	Tumor necrosis factor alpha receptors; Myenteric ganglia; Enteric neurons; Neuronal environment; Diabetes; Insulin
Core Tip	Our findings demonstrate an intestinal segment-specific expression of TNFRs in myenteric ganglia and their muscular environment in type 1 diabetic rats. TNFR2 density was significantly altered only in the duodenum of diabetics with decrease in the ganglia, while no significant changes in TNFR1 was observed. In diabetic muscle/myenteric plexus homogenates, the levels of both TNFRs decreased robustly in the duodenum, which markedly influenced the TNFR2/TNFR1 proportion both in the ganglia and muscular environment. These results highlight that TNFR2 is more affected than TNFR1 in myenteric ganglia in the duodenum of diabetic rats. Insulin treatment had controversial effects on TNFR expression.
Publish Date	2023-01-10 08:58
Citation	Barta BP, Onhausz B, AL Doghmi A, Szalai Z, Balázs J, Bagyánszki M, Bódi N. Gut region-specific TNFR expression: TNFR2 is more affected than TNFR1 in duodenal myenteric ganglia of diabetic rats. World J Diabetes 2023; 14(1): 48-61
URL	https://www.wjgnet.com/1948-9358/full/v14/i1/48.htm
DOI	https://dx.doi.org/10.4239/wjd.v14.i1.48

Full Article (PDF)	WJD-14-48.pdf
Full Article (Word)	WJD-14-48.docx
Manuscript File	78491_Auto_Edited-Ma JY.docx
Answering Reviewers	78491-Answering reviewers.pdf
Audio Core Tip	78491-Audio core tip.m4a
Biostatistics Review Certificate	78491-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	78491-Conflict-of-interest statement.pdf
Copyright License Agreement	78491-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	78491-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	78491-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	78491-Language certificate.pdf
Peer-review Report	78491-Peer-review(s).pdf
Scientific Misconduct Check	78491-Bing-Gao CC-2.png
Scientific Editor Work List	78491-Scientific editor work list.pdf