| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Xiaojianzhong decoction prevents gastric precancerous lesions in rats by inhibiting autophagy and glycolysis in gastric mucosal cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Xiang Zhang, Sheng-Chuan Bao, Juan Chen, Ting Chen, Hai-Liang Wei, Xiao-Yan Zhou, Jing-Tao Li and Shu-Guang Yan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shaanxi Science and Technology overall Planning and Innovation Project |
2016KTTSSF01-05 |
| Key R & D projects in Shaanxi Province |
2022ZDLSF05-10 |
| Shaanxi University of Chinese Medicine Discipline Innovation Team Construction Project |
2019-YL-05 |
|
| Corresponding Author |
Shu-Guang Yan, PhD, Professor, College of Basic Medicine, Shaanxi University of Chinese Medicine, Century Avenue, Qindu District, Xianyang 712046, Shaanxi Province, China. ysg2002.student@sina.com |
| Key Words |
Xiaojianzhong decoction; Gastric precancerous lesions; Autophagy; Glycolysis; Gastric mucosal cells; Herb |
| Core Tip |
Xiaojianzhong Decoction is a classic compound for the treatment of digestive system diseases in ancient China, and it also shows good curative effect in the treatment of gastric precancerous lesions (GPL). Many studies have shown that the levels of autophagy and glycolysis influence the progression of GPL. Our study found that Xiaojianzhong Decoction can improve the pathological manifestations of gastric mucosa in GPL rats, and inhibits the expression of autophagy, glycolysis-related proteins and mRNA. Xiaojianzhong decoction (XJZ) prevented the increase of autophagy levels by decreasing gastric mucosal hypoxia, activating the phosphatidylinositol 3-kimase/protein kinase B/mammalian target of rapamycin pathway, inhibiting the p53/AMP-activated protein kinase pathway activation and Unc-51 Like kinase 1 (ULK1) Ser-317 and Ser-555 phosphorylation. In addition, XJZ improved abnormal gastric mucosal glucose metabolism by ameliorating gastric mucosal hypoxia and inhibiting ULK1 expression. |
| Publish Date |
2023-03-15 02:14 |
| Citation |
Zhang JX, Bao SC, Chen J, Chen T, Wei HL, Zhou XY, Li JT, Yan SG. Xiaojianzhong decoction prevents gastric precancerous lesions in rats by inhibiting autophagy and glycolysis in gastric mucosal cells. World J Gastrointest Oncol 2023;15(3): 464-489 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i3/464.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i3.464 |
