Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	80069
Country	Taiwan

Received	2022-09-16 15:27
Peer-Review Started	2022-09-16 15:29
To Make the First Decision
Return for Revision	2022-10-20 14:34
Revised	2022-11-03 07:29
Second Decision	2022-12-07 03:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-12-07 18:13
Articles in Press	2022-12-07 18:13
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-12-11 19:14
Typeset the Manuscript	2023-01-03 06:20
Publish the Manuscript Online	2023-01-10 08:49

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Roles of conventional and complementary therapies in recurrent hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Hsiang-Chun Lai, Hung-Jen Lin, Long-Bin Jeng and Sheng-Teng Huang
ORCID	Author(s) ORCID Number Hsiang-Chun Lai http://orcid.org/0000-0001-7885-619X Hung-Jen Lin http://orcid.org/0000-0002-0736-3192 Long-Bin Jeng http://orcid.org/0000-0002-2928-4698 Sheng-Teng Huang http://orcid.org/0000-0002-7495-6115
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Technology of Taiwan NSTC111-2320-B-039-025 China Medical University Hospital DMR-111-005 China Medical University Hospital DMR-111-013 China Medical University Hospital DMR-111-016 China Medical University Hospital DMR-111-195 An-Nan Hospital, China Medical University ANHRF-110-25
Corresponding Author	Sheng-Teng Huang, MD, PhD, Chief Doctor, Professor, Staff Physician, Department of Chinese Medicine, China Medical University Hospital, No. 2 Yude Road, North District, Taichung 40447, Taiwan. sheng.teng@yahoo.com
Key Words	Recurrence; Hepatocellular carcinoma; Complementary therapy; Traditional Chinese medicine; Cancer stemness; Drug resistance
Core Tip	Studies report a recurrence rate for hepatocellular carcinoma of up to 70%-80% after 5 years of follow-up. Controlling tumor recurrence is the most critical factor associated with hepatocellular carcinoma (HCC) mortality. Although, conventional salvage therapies, including re-hepatectomy, transcatheter arterial chemoembolization, target therapy, immunotherapy have yet to achieve favorable outcomes. Complementary therapies as an adjuvant treatment modality may strengthen and augment conventional therapies. We herein discuss the molecular mechanisms underlying complementary therapies and the interactions with conventional therapy in recurrent HCC related to augmenting the local control, inhibiting epithelial-mesenchymal transition, migration, invasion, metastasis and cancer stem cells, and by ameliorating drug resistance.
Publish Date	2023-01-10 08:49
Citation	Lai HC, Lin HJ, Jeng LB, Huang ST. Roles of conventional and complementary therapies in recurrent hepatocellular carcinoma. World J Gastrointest Oncol 2023; 15(1): 19-35
URL	https://www.wjgnet.com/1948-5204/full/v15/i1/19.htm
DOI	https://dx.doi.org/10.4251/wjgo.v15.i1.19

Full Article (PDF)	WJGO-15-19.pdf
Full Article (Word)	WJGO-15-19.docx
Manuscript File	80069-Review-Filipodia.docx
Answering Reviewers	80069-Answering reviewers.pdf
Audio Core Tip	80069-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	80069-Conflict-of-interest statement.pdf
Copyright License Agreement	80069-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	80069-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	80069-Language certificate.pdf
Peer-review Report	80069-Peer-review(s).pdf
Scientific Misconduct Check	80069-Bing-Fan JR-2.png
Scientific Editor Work List	80069-Scientific editor work list.pdf