| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Substance Abuse |
| Manuscript Type |
Case Report |
| Article Title |
High doses of dextromethorphan induced shock and convulsions in a 19-year-old female: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shintaro Shimozawa, Daisuke Usuda, Toru Sasaki, Shiho Tsuge, Riki Sakurai, Kenji Kawai, Shun Matsubara, Risa Tanaka, Makoto Suzuki, Yuta Hotchi, Shungo Tokunaga, Ippei Osugi, Risa Katou, Sakurako Ito, Suguru Asako, Kentaro Mishima, Akihiko Kondo, Keiko Mizuno, Hiroki Takami, Takayuki Komatsu, Jiro Oba, Tomohisa Nomura and Manabu Sugita |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shintaro Shimozawa, MD, Doctor, Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima-city 177-8521, Tokyo, Japan. shin46260707@gmail.com |
| Key Words |
Dextromethorphan; Drug overdose; Shock; Symptom; Treatment; Case report |
| Core Tip |
Prior studies have posited that dextromethorphan acts as a voltage-gated calcium channel inhibitor, one of its mechanisms of action. It is possible that the high dose in the present case amplified this effect. Previous reports attributed fatalities to central nervous system and respiratory depression, yet shock may also be a contributing factor, as evidenced by this case. This may be a rare occurrence, as it was only observed in the emergency room. We reported the first case of shock caused by an overdose of dextromethorphan. We were able to save the patient’s life in intensive care. |
| Publish Date |
2023-06-02 11:04 |
| Citation |
Shimozawa S, Usuda D, Sasaki T, Tsuge S, Sakurai R, Kawai K, Matsubara S, Tanaka R, Suzuki M, Hotchi Y, Tokunaga S, Osugi I, Katou R, Ito S, Asako S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Oba J, Nomura T, Sugita M. High doses of dextromethorphan induced shock and convulsions in a 19-year-old female: A case report. World J Clin Cases 2023; 11(16): 3870-3876 |
| URL |
https://www.wjgnet.com/2307-8960/full/v11/i16/3870.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i16.3870 |
