Publication Name	World Journal of Gastroenterology
Manuscript ID	80793
Country	Poland

Received	2022-10-12 21:31
Peer-Review Started	2022-10-12 21:35
To Make the First Decision
Return for Revision	2022-11-15 03:31
Revised	2022-11-22 14:44
Second Decision	2023-01-09 04:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-09 22:34
Articles in Press	2023-01-09 22:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-01-15 21:53
Typeset the Manuscript	2023-01-30 07:07
Publish the Manuscript Online	2023-02-10 09:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Virology
Manuscript Type	Review
Article Title	Decade of optimizing therapy with direct-acting antiviral drugs and the changing profile of patients with chronic hepatitis C
Manuscript Source	Invited Manuscript
All Author List	Michał Brzdęk, Dorota Zarębska-Michaluk, Federica Invernizzi, Marta Cilla, Krystyna Dobrowolska and Robert Flisiak
ORCID	Author(s) ORCID Number Michał Brzdęk http://orcid.org/0000-0002-1180-9230 Dorota Zarębska-Michaluk http://orcid.org/0000-0003-0938-1084 Robert Flisiak http://orcid.org/0000-0003-3394-1635
Funding Agency and Grant Number
Corresponding Author	Dorota Zarębska-Michaluk, PhD, Professor, Department of Infectious Diseases, Jan Kochanowski University, Radiowa 7, Kielce 25-516, Poland. dorota1010@tlen.pl
Key Words	Hepatitis C virus; Interferon; Direct-acting antiviral; Epidemiology; Chronic hepatitis C
Core Tip	The decade ago, direct-acting antiviral drugs were introduced that have greatly improved the effectiveness of treatment for patients with hepatitis C virus (HCV) infection. The new drugs have increased the chances of eliminating HCV infection as a significant public threat. This paper describes changes in the therapeutic options administered over the past decade and documents the changing patient profile over the years in the interferon (IFN)-free era. Special populations of difficult-to-treat patients in the IFN era, currently not meeting this definition, are highlighted.
Publish Date	2023-02-10 09:15
Citation	Brzdęk M, Zarębska-Michaluk D, Invernizzi F, Cilla M, Dobrowolska K, Flisiak R. Decade of optimizing therapy with direct-acting antiviral drugs and the changing profile of patients with chronic hepatitis C. World J Gastroenterol 2023; 29(6): 949-966
URL	https://www.wjgnet.com/1007-9327/full/v29/i6/949.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i6.949

Full Article (PDF)	WJG-29-949.pdf
Full Article (Word)	WJG-29-949.docx
Manuscript File	80793-Review-Filipodia.docx
Answering Reviewers	80793-Answering reviewers.pdf
Audio Core Tip	80793-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	80793-Conflict-of-interest statement.pdf
Copyright License Agreement	80793-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	80793-Language certificate.pdf
Peer-review Report	80793-Peer-review(s).pdf
Scientific Editor Work List	80793-Scientific editor work list.pdf