Publication Name	World Journal of Transplantation
Manuscript ID	33493
Country	Saudi Arabia

Received	2017-02-13 13:49
Peer-Review Started	2017-02-15 09:03
To Make the First Decision	2017-03-27 12:15
Return for Revision	2017-03-27 16:37
Revised	2017-07-06 21:14
Second Decision	2017-07-18 09:31
Accepted by Journal Editor-in-Chief	2017-07-20 11:09
Accepted by Executive Editor-in-Chief	2017-07-24 05:11
Articles in Press	2017-07-24 05:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-18 07:54
Publish the Manuscript Online	2017-08-22 07:27

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Transplantation
Manuscript Type	Observational Study
Article Title	Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia
Manuscript Source	Invited Manuscript
All Author List	Moussab Damlaj, Samer Ghazi, Walid Mashaqbeh, Gamal Gmati, Hend Salama, Khadega A Abuelgasim, Mushtaq Rather, Ali Hajeer, Mohsen Al-Zahrani, Abdul-Rahman Jazieh, Ayman Hejazi and Ahmad Al Askar
Funding Agency and Grant Number
Corresponding Author	Moussab Damlaj, FACP, FRCP (C), MD, Division of Hematology and HSCT, Department of Oncology, King Abdulaziz Medical City, P.O. Box 22490, Riyadh 11426, Saudi Arabia. damlajmo@ngha.med.sa
Key Words	Acute leukemia; Allogeneic transplant; Absolute lymphocyte count
Core Tip	Disease relapse remains the most common cause of treatment failure after allogeneic hematopoietic stem cell transplantation for acute leukemia. Previous studies have identified that early lymphocyte recovery can be a surrogate of graft vs leukemia effect hence identifying high risk patients for relapse. However, published reports are heterogeneous with regards to timeline and magnitude of lymphocyte recovery. Using receiver operator characteristics with area under the curve, we identified that absolute lymphocyte count > 0.3 × 109/L at day 14 is associated with half the relapse risk which was statistically significant at the multivariable analysis. There was a trend towards improved progression free survival and overall survival for patients with early lymphocyte recovery. In conclusion, we observed that lymphocyte recovery is an independent predictor of relapse in allogeneic transplant recipients for acute leukemia. This would help identify high risk patients who may benefit from maintenance strategies post-transplant.
Publish Date	2017-08-22 07:27
Citation	Damlaj M, Ghazi S, Mashaqbeh W, Gmati G, Salama H, Abuelgasim KA, Rather M, Hajeer A, Al-Zahrani M, Jazieh AR, Hejazi A, Al Askar A. Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia. World J Transplant 2017; 7(4): 235-242
URL	http://www.wjgnet.com/2220-3230/full/v7/i4/235.htm
DOI	http://dx.doi.org/10.5500/wjt.v7.i4.235

Full Article (PDF)	WJT-7-235.pdf
Full Article (Word)	WJT-7-235.doc
Manuscript File	33493-Review.docx
Answering Reviewers	33493-Answering-Reviewers-revision.docx
Audio Core Tip	33493-Audio-revision.mp3
Biostatistics Review Certificate	33493-Biostatistics-Statement-revision.docx
Conflict-of-Interest Disclosure Form	33493-Conflict-of-Interest-Statement-revision.docx
Copyright License Agreement	33493-Copyright-Assignment-revision.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	33493-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s)-revision.docx
Signed Informed Consent Form(s) or Document(s)	33493-Informed-Consent-Statement-revision.docx
Institutional Review Board Approval Form or Document	33493-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	33493-Non-Native-Speakers-of-English-revision.docx
Peer-review Report	33493-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33493-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	33493-Scientific misconduct check.pdf
Scientific Editor Work List	33493-Scientific editor work list.pdf