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Articles Published Processes
8/21/2020 1:38:19 AM | Browse: 429 | Download: 1414
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Received |
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2020-01-20 12:43 |
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Peer-Review Started |
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2020-01-20 12:43 |
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To Make the First Decision |
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Return for Revision |
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2020-04-22 09:10 |
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Revised |
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2020-05-21 13:01 |
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Second Decision |
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2020-07-01 10:29 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-07-01 22:33 |
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Articles in Press |
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2020-07-01 22:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-07-13 06:46 |
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Typeset the Manuscript |
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2020-07-28 07:58 |
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Publish the Manuscript Online |
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2020-08-21 01:38 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Observational Study |
| Article Title |
Mutational analysis of Ras hotspots in patients with urothelial carcinoma of the bladder
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kiran Tripathi, Apul Goel, Atin Singhai and Minal Garg |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Science and Technology, Govt. of India |
SR/SO/HS-0113/2010 |
| University Grants Commission (UGC), Govt. of India |
22/12/2013(ii)EU-V |
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| Corresponding Author |
Minal Garg, MSc, PhD, Assistant Professor, Doctor, Doctor, Department of Biochemistry, University of Lucknow, University Road, Lucknow 226007, India. minal14@yahoo.com |
| Key Words |
Coding exons; Oncogenic activation; Polymerase chain reaction - restriction fragment length polymorphism; Point mutations; Ras genes; Urothelial carcinoma of bladder |
| Core Tip |
Mutant Ras is shown to be associated with drug resistance, enhanced metastasis and shorter survival of patients. Owing to reported heterogeneity among distribution of the most frequent mutations in Ras isoforms in different patients’ populations with urothelial carcinoma of bladder, it is necessary to examine the patients for Ras mutations in order to prognose disease clinical outcome. Our findings on the lack of Ras mutations could be explained on the basis of different etiological mechanisms involved in tumor development, inherent genetic susceptibility, tissue specificity or alternative Ras dysfunction including gene amplification or overexpression in a given cohort of patients. |
| Publish Date |
2020-08-21 01:38 |
| Citation |
Tripathi K, Goel A, Singhai A, Garg M. Mutational analysis of Ras hotspots in patients with urothelial carcinoma of the bladder. World J Clin Oncol 2020; 11(8): 614-628 |
| URL |
https://www.wjgnet.com/2218-4333/full/v11/i8/614.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v11.i8.614 |
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