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Articles Published Processes
5/26/2020 2:31:16 PM | Browse: 1054 | Download: 2384
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Received |
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2020-02-24 09:37 |
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Peer-Review Started |
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2020-02-24 09:38 |
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First Decision by Editorial Office Director |
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2020-03-28 12:54 |
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Return for Revision |
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2020-03-28 12:54 |
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Revised |
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2020-04-03 14:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-04-20 07:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-04-23 21:58 |
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Articles in Press |
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2020-04-23 21:58 |
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Edit the Manuscript by Language Editor |
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2020-04-29 01:16 |
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Typeset the Manuscript |
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2020-05-25 05:39 |
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Publish the Manuscript Online |
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2020-05-26 14:31 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Obstetrics & Gynecology |
| Manuscript Type |
Basic Study |
| Article Title |
Safety of menstrual blood-derived stromal cell transplantation in treatment of intrauterine adhesion
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qi-Yuan Chang, Si-Wen Zhang, Ping-Ping Li, Zheng-Wei Yuan and Ji-Chun Tan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program |
2018YFC1002105 |
| Key Research and Development Program of Liaoning Province |
2018020222 |
| Major Special Construction Plan for Discipline Construction Project of China Medical University |
3110118033 |
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| Corresponding Author |
Ji-Chun Tan, PhD, Doctor, Doctor, Professor, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang 110022, Liaoning Province, China. tjczjh@163.com |
| Key Words |
Menstrual blood-derived stromal cells; Endometrial treatment; Intrauterine adhesion; Stem cell transplantation; Biosafety; Toxicity |
| Core Tip |
Menstrual-derived stromal stem cells (MenSCs) with high proliferative capacity and self-renewal ability have a powerful therapeutic effect in patients with severe intrauterine adhesion. However, safety assessment of MenSCs transplantation is an essential for its further application. Here, we evaluate the short-, medium-, and long-term biosafety of MenSCs via intrauterine transplantation in intrauterine adhesion rat model, with a special focus on toxicity and tumorigenicity. There was no acute, sub-chronic or chronic poisoning, infection, tumor and endometriosis in the rat with intrauterine adhesions after MenSCs transplantation, highlighting that intrauterine transplantation of MenSCs is safe for endometrial treatment. |
| Publish Date |
2020-05-26 14:31 |
| Citation |
Chang QY, Zhang SW, Li PP, Yuan ZW, Tan JC. Safety of menstrual blood-derived stromal cell transplantation in treatment of intrauterine adhesion. World J Stem Cells 2020; 12(5): 368-380 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i5/368.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i5.368 |
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