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Articles Published Processes
6/18/2021 5:06:16 AM | Browse: 398 | Download: 979
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Received |
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2021-01-29 02:19 |
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Peer-Review Started |
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2021-01-29 02:20 |
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To Make the First Decision |
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Return for Revision |
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2021-03-14 06:07 |
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Revised |
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2021-03-23 09:57 |
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Second Decision |
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2021-05-07 13:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-05-07 14:10 |
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Articles in Press |
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2021-05-07 14:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-06-07 04:55 |
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Typeset the Manuscript |
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2021-06-16 02:47 |
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Publish the Manuscript Online |
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2021-06-18 05:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Review |
| Article Title |
Silencing hepatitis B virus covalently closed circular DNA: The potential of an epigenetic therapy approach
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Prashika Singh, Dylan Kairuz, Patrick Arbuthnot and Kristie Bloom |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kristie Bloom, MSc, PhD, Academic Research, Research Scientist, Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, University of the Witwatersrand, Private Bag 3, Wits, Johannesburg 2050, Gauteng, South Africa. kristie.bloom@wits.ac.za |
| Key Words |
Chronic hepatitis B virus; Epigenetic gene silencing; Functional cure; Hepatocellular carcinoma; Hepatitis B surface antigen |
| Core Tip |
Epigenetic regulation of the hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) minichromosome is important for establishing and maintaining infection. To do this HBV manipulates several cellular pathways, resulting in an intricate and complex interplay between the virus and the host. Epigenetic silencing of the cccDNA could permanently inhibit viral transcription. Therapies such as immune modulators, small molecules, and epigenome engineering tools could silence HBV DNA to promote a functional cure. |
| Publish Date |
2021-06-18 05:06 |
| Citation |
Singh P, Kairuz D, Arbuthnot P, Bloom K. Silencing hepatitis B virus covalently closed circular DNA: The potential of an epigenetic therapy approach. World J Gastroenterol 2021; 27(23): 3182-3207 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i23/3182.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i23.3182 |
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