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Articles Published Processes
7/23/2021 1:30:21 PM | Browse: 552 | Download: 1076
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Received |
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2021-02-21 22:04 |
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Peer-Review Started |
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2021-02-21 22:08 |
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To Make the First Decision |
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Return for Revision |
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2021-04-20 02:30 |
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Revised |
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2021-05-03 13:58 |
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Second Decision |
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2021-06-22 08:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-06-22 10:02 |
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Articles in Press |
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2021-06-22 10:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-07-21 13:52 |
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Publish the Manuscript Online |
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2021-07-23 13:30 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Bruno C Menarim, James N MacLeod and Linda A Dahlgren |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Bruno C Menarim, DVM, MSc, PhD, Senior Postdoctoral Fellow, Gluck Equine Research Center, Department of Veterinary Science, College of Agriculture, Food and Environment, University of Kentucky, 1400 Nicholasville , Lexington, KY 40546, United States. bruno.menarim@uky.edu |
| Key Words |
Osteoarthritis; Arthropathy; Synovitis; Hematopoietic progenitor; Homeostasis; Cell therapy |
| Core Tip |
Synovial macrophages are essential for joint integrity. Following injury, macrophages incite inflammation recruiting more macrophages from the bone marrow to counteract damage and promote tissue repair. Synovial macrophages are further essential to resolve inflammation recovering joint homeostasis. However, sustained damage frequently overwhelms pro-resolving functions of synovial macrophages, leading to chronic inflammation and degeneration. This review summarizes the dual role of macrophages in the maintenance of joint homeostasis and the emergent therapeutic use of macrophage progenitors isolated from the bone marrow to promote endogenous resolution of joint inflammation and recovery of homeostasis, while preserving physiological mechanisms negatively affected by anti-inflammatories. |
| Publish Date |
2021-07-23 13:30 |
| Citation |
Menarim BC, MacLeod JN, Dahlgren LA. Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair. World J Stem Cells 2021; 13(7): 825-840 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i7/825.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i7.825 |
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