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Articles Published Processes
11/17/2021 2:18:21 AM | Browse: 769 | Download: 1360
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Received |
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2021-03-02 01:41 |
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Peer-Review Started |
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2021-03-02 01:43 |
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First Decision by Editorial Office Director |
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2021-06-05 04:56 |
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Return for Revision |
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2021-06-05 04:56 |
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Revised |
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2021-06-09 01:25 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-08-23 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-08-23 07:59 |
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Articles in Press |
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2021-08-23 07:59 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-11-11 02:14 |
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Publish the Manuscript Online |
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2021-11-17 02:18 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Review |
| Article Title |
Agmatine as a novel candidate for rapid-onset antidepressant response
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ana Paula Valverde, Anderson Camargo and Ana Lúcia S Rodrigues |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Conselho Nacional de Desenvolvimento Científico e Tecnológico |
310113/2017-2 |
| CNPq Research Productivity Fellowship |
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| Corresponding Author |
Ana Lúcia S Rodrigues, PhD, Full Professor, Department of Biochemistry, Campus Universitário, Center for Biological Sciences, Universidade Federal de Santa Catarina, Rod. SC-401 S/N, Florianopolis 88040900, SC, Brazil. alsrodri@gmail.com |
| Key Words |
Agmatine; Fast-acting antidepressants; Ketamine; Major depressive disorder; Microbiota-gut-brain axis; Neuroinflammation |
| Core Tip |
One of the main challenges in the advancement of antidepressant therapy is the establishment of safe and effective fast-acting antidepressants. Ketamine is a prototype for rapid-onset antidepressant responses. Agmatine has been shown to produce fast antidepressant-like effect by stimulating mechanistic target of rapamycin complex 1 signaling pathway, similar to ketamine. Moreover, NLR family pyrin domain containing 3 and microbiota-gut-brain axis may be novel targets for fast antidepressant responses. These targets have also been postulated to play a role in the antidepressant effect of both ketamine and agmatine. |
| Publish Date |
2021-11-17 02:18 |
| Citation |
Valverde AP, Camargo A, Rodrigues ALS. Agmatine as a novel candidate for rapid-onset antidepressant response. World J Psychiatr 2021; 11(11): 981-996 |
| URL |
https://www.wjgnet.com/2220-3206/full/v11/i11/981.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v11.i11.981 |
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