Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	70492
Country	China

Received	2021-08-05 00:53
Peer-Review Started	2021-08-05 00:56
To Make the First Decision
Return for Revision	2021-10-03 21:03
Revised	2021-10-09 06:55
Second Decision	2022-01-06 03:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-06 19:08
Articles in Press	2022-01-06 19:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-04 22:46
Typeset the Manuscript	2022-02-07 01:54
Publish the Manuscript Online	2022-02-10 14:26

ISSN	1948-5204 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Comprehensive molecular characterization and identification of prognostic signature in stomach adenocarcinoma on the basis of energy-metabolism-related genes
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Jia Chang, Xiao-Yu Wang, Wei Zhang, Cong Tan, Wei-Qi Sheng and Mi-Die Xu
ORCID	Author(s) ORCID Number Jin-Jia Chang http://orcid.org/0000-0002-9105-8691 Xiao-Yu Wang http://orcid.org/0000-0002-7280-7327 Wei Zhang http://orcid.org/0000-0002-7622-9018 Cong Tan http://orcid.org/0000-0001-6912-4579 Wei-Qi Sheng http://orcid.org/0000-0002-8726-277X Mi-Die Xu http://orcid.org/0000-0003-1775-6608
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) 81972249 National Natural Science Foundation of China (General Program) 81802367 National Natural Science Foundation of China (General Program) 81802361 National Natural Science Foundation of China (General Program) 82172702 Shanghai Clinical Research Plan of SHDC SHDC2020CR4068 Shanghai Clinical Science and Technology Innovation Project of Municipal Hospital SHDC12020102 Shanghai Science and Technology Development Fund 18ZR1408000 Shanghai Science and Technology Development Fund 21ZR1414900 Shanghai Science and Technology Development Fund 19MC1911000 Clinical Research Project of Shanghai Municipal Health Committee 20194Y0348 Shanghai “Rising Stars of Medical Talents” Youth Development Program Youth Medical Talents – Specialist Program SHWSRS(2020)_087
Corresponding Author	Wei-Qi Sheng, PhD, Chief Doctor, Director, Professor, Teacher, Department of Pathology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai 200032, China. shengweiqi2006@163.com
Key Words	Gastric cancer; Molecular subtype; Energy-metabolism-related genes; Prognosis factor; Roadmap
Core Tip	On the basis of 86 EMRGs that were significantly associated to patients’ progression-free survival (PFS), we propose a molecular classification dividing stomach adenocarcinoma into two subtypes: Cluster 1, most of which are young patients and display more immune and stromal cell components in tumor microenvironment and lower tumor priority; and Cluster 2, which show early stages and better PFS. Moreover, by using a three-phase training, test and validation process, we construct a 6-gene signature that can classify the prognostic risk of patients, and which present higher robustness and clinical usability compared with three previous reported prognostic gene signatures.
Publish Date	2022-02-10 14:26
Citation	Chang J, Wang X, Zhang W, Tan C, Sheng W, Xu M. Comprehensive molecular characterization and identification of prognostic signature in stomach adenocarcinoma on the basis of energy-metabolism-related genes. World J Gastrointest Oncol 2022; 14(2): 478-497
URL	https://www.wjgnet.com/1948-5204/full/v14/i2/478.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i2.478

Full Article (PDF)	WJGO-14-478.pdf
Full Article (Word)	WJGO-14-478.docx
Manuscript File	70492_Auto_Edited-LLW-Filipodia.docx
Answering Reviewers	70492-Answering reviewers.pdf
Audio Core Tip	70492-Audio core tip.m4a
Biostatistics Review Certificate	70492-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	70492-Conflict-of-interest statement.pdf
Copyright License Agreement	70492-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	70492-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	70492-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	70492-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	70492-Language certificate.pdf
Supplementary Material	70492-Supplementary material.pdf
Peer-review Report	70492-Peer-review(s).pdf
Scientific Misconduct Check	70492-Bing-Wang LL-2.png
Scientific Editor Work List	70492-Scientific editor work list.pdf