| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Coptis, Pinellia, and Scutellaria as a promising new drug combination for treatment of Helicobacter pylori infection
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhang Yu, Wu-Dong Sheng, Xu Yin and Yu Bin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Domestic First-class Construction Disciplines of the Hunan University of Chinese Medicine |
2018[03] |
| Key Scientific Research Project of Hunan Provincial Education Board |
20A371 |
| Key Programs of Administration of Traditional Chinese Medicine of Hunan Province |
C2022016 |
|
| Corresponding Author |
Yu Bin, MM, Chief Physician, Professor, Department of Internal Medicine, The First Hospital of Hunan University of Chinese Medicine, No. 95 Shaoshan Middle Road, Yuhua District, Changsha 410007, Hunan Province, China. yubin410@163.com |
| Key Words |
Coptis; Pinellia; Scutellaria; Anti-Helicobacter pylori; Drug combination; Traditional Chinese medicine |
| Core Tip |
Infection with Helicobacter pylori ( H. pylori ) is associated with severe digestive diseases, while successful eradication of this pathogen is known to prevent the occurrence of peptic ulcer disease and gastric cancer. Traditional Chinese medicine (TCM) has unique advantages for treating H. pylori infection, which can reduce drug resistance and increase the eradication rate of H. pylori. Here, we attempt to identify medication rules, effective materials, and the molecular mechanisms underlying the therapeutic effect of TCM against H. pylori using data mining, in vivo experiment, and network pharmacology. Coptis, Pinellia, and Scutellaria (CPS) was identified as the core drug combination for H. pylori eradication.We evidenced that CPS can eradicated H. pylori, alleviated the gastric pathology, and reduced circulating TNF-α and IL-1β levels. Nine key compounds and nine hub target proteins were further determined as the key active ingredients and therapeutic targets of CPS against H. pylori respectively. Altogether, our data strongly suggest that the efficacy of CPS in the treatment of H. pylori is worthy of affirmation. |
| Publish Date |
2022-12-02 12:50 |
| Citation |
Yu Z, Sheng WD, Yin X, Bin Y. Coptis, Pinellia, and Scutellaria as a promising new drug combination for treatment of Helicobacter pylori infection. World J Clin Cases 2022; 10(34):12500-12514 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i34/12500.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i34.12500 |
