| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue-Hong Kong, Mei-Ling Xu, Jun-Jun Zhang, Guang-Qiang Chen, Zhi-Hui Hong, Hong Zhang, Xiao-Xiao Dai, Yi-Fu Ma, Xiang-Rong Zhao, Chen-Yang Zhang, Rong-Zheng Chen, Peng-Fei Xing and Li-Yuan Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Suzhou Medical Center |
Szlcyxzx202103 |
| National Natural Science Foundation of China |
82171828 |
| Key R&D Plan of Jiangsu Province (Social Development) |
BE2021652 |
| Subject Construction Support Project of The Second Affiliated Hospital of Soochow University |
XKTJHRC20210011 |
| Wu Jieping Medical Foundation |
320.6750.2021-01-12 |
| Special Project of “Technological Innovation” Project of CNNC Medical Industry Co. Ltd |
ZHYLTD2021001 |
| Suzhou Science and Education Health Project |
KJXW2021018 |
| Foundation of Chinese Society of Clinical Oncology |
Y-pierrefabre202102-0113 |
| Beijing Bethune Charitable Foundation |
STLKY0016 |
| Research Projects of China Baoyuan Investment Co. |
270004 |
| Suzhou Gusu Health Talent Program |
GSWS2022028 |
| Open Project of State Key Laboratory of Radiation Medicine and Protection of Soochow University |
GZN1202302 |
|
| Corresponding Author |
Li-Yuan Zhang, PhD, Chief Physician, Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou 215000, Jiangsu Province, China. zhangliyuan@suda.edu.cn |
| Key Words |
Pancreatic ductal adenocarcinoma; PRaG 3.0 therapy; Human epidermal growth factor receptor 2; Novel combination therapy; Case report |
| Core Tip |
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death worldwide. Herein, we present a case of multiple metastatic PDAC with immunohistochemistry (IHC) mismatch repair proficient but human epidermal growth factor receptor 2 (HER-2) IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment. A novel combination therapy PRaG 3.0 of RC48 (HER2-antibody-drug conjugate), radiotherapy, PD-1 inhibitor, granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months. We proposed that PRaG 3.0 might be a good therapeutic strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy. |
| Publish Date |
2024-03-06 06:10 |
| Citation |
Kong YH, Xu ML, Zhang JJ, Chen GQ, Hong ZH, Zhang H, Dai XX, Ma YF, Zhao XR, Zhang CY, Chen RZ, Xing PF, Zhang LY. PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma: A case report. World J Gastroenterol 2024; 30(9): 1237-1249 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i9/1237.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i9.1237 |
