Publication Name	World Journal of Clinical Cases
Manuscript ID	91841
Country	China

Received	2024-01-07 07:11
Peer-Review Started	2024-01-07 07:11
First Decision by Editorial Office Director	2024-01-16 07:41
Return for Revision	2024-01-16 13:33
Revised	2024-01-23 11:52
Publication Fee Transferred
Second Decision by Editor	2024-02-27 03:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-02-27 07:33
Articles in Press	2024-02-27 07:33
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-18 12:41
Publish the Manuscript Online	2024-03-25 08:14

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Translational Research
Article Title	Exploring the autophagy-related pathogenesis of active ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Zhuo-Zhi Gong, Teng Li, He Yan, Min-Hao Xu, Yue Lian, Yi-Xuan Yang, Wei Wei and Tao Liu
ORCID	Author(s) ORCID Number Tao Liu http://orcid.org/0009-0007-0428-4986
Funding Agency and Grant Number
Corresponding Author	Tao Liu, PhD, Associate Professor, Chief Doctor, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, China. ltlyf2@163.com
Key Words	Ulcerative colitis; Autophagy; Bioinformatic; Targets; Pathogenesis
Core Tip	This study used bioinformatics to explore the autophagy-related pathogenesis of ulcerative colitis (UC) during its active phase. A total of 58 differentially expressed autophagy-related genes (DEARGs) were found in gene expression datasets from UC patients and healthy controls. Of these, SERPINA1, BAG3, HSPA5, CASP1, and CX3CL1 were identified as core targets. Enrichment analysis highlighted the involvement of DEARGs in autophagy regulation, and macroautophagy, in addition to NOD-like receptor signaling and other pathways. These DEARGs were also shown to be associated with diseases like malignant glioma and middle cerebral artery occlusion. Immune infiltration analysis revealed an increased presence of immune cells, including activated memory CD4 T cells and follicular helper T cells in active UC patients than in healthy controls. This study suggests that autophagy plays a significant role in the active phase of UC and identifies potential targets for novel UC treatments.
Publish Date	2024-03-25 08:14
Citation	Gong ZZ, Li T, Yan H, Xu MH, Lian Y, Yang YX, Wei W, Liu T. Exploring the autophagy-related pathogenesis of active ulcerative colitis. World J Clin Cases 2024; 12(9): 1622-1633
URL	https://www.wjgnet.com/2307-8960/full/v12/i9/1622.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i9.1622

Full Article (PDF)	WJCC-12-1622-with-cover.pdf