ISSN |
1948-5182 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Naruemon Klaikeaw, Jutamas Wongphoom, Duangporn Werawatganon, Maneerat Chayanupatkul and Prasong Siriviriyakul |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Grant of Ratchadaphiseksomphot, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand |
RA59/035 |
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Corresponding Author |
Duangporn Werawatganon, MD, MSc, Professor, Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases Research Unit, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Henri Dunant Road, Pathumwan, Bangkok 10330, Thailand. dr.duangporn@gmail.com |
Key Words |
Non-alcoholic steatohepatitis; Aloe vera; Oxidative stress; Hepatic inflammation; Hepatocyte apoptosis; Peroxisome proliferators-activated receptor |
Core Tip |
To the best of our knowledge, this is the first study to evaluate the therapeutic effects of aloe vera in non-alcoholic steatohepatitis (NASH). In this animal model of NASH, we found that aloe vera could decrease oxidative stress markers, replenish natural antioxidants, and reduce hepatic inflammation and hepatocyte apoptosis. Aloe vera could, in sum, alleviate the pathologic changes seen in NASH. |
Publish Date |
2020-07-23 05:00 |
Citation |
Klaikeaw N, Wongphoom J, Werawatganon D, Chayanupatkul M, Siriviriyakul P. Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis. World J Hepatol 2020; 12(7): 363-377 |
URL |
https://www.wjgnet.com/1948-5182/full/v12/i7/363.htm |
DOI |
https://dx.doi.org/10.4254/wjh.v12.i7.363 |