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4/2/2021 12:29:14 PM | Browse: 27 | Download: 109
Publication Name World Journal of Clinical Cases
Manuscript ID 61768
Country/Territory China
Received
2020-12-21 11:29
Peer-Review Started
2020-12-18 01:47
To Make the First Decision
Return for Revision
2021-01-17 06:14
Revised
2021-01-18 05:36
Second Decision
2021-01-30 14:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-02-01 19:12
Articles in Press
2021-02-01 19:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-02-09 00:45
Typeset the Manuscript
2021-03-16 05:59
Publish the Manuscript Online
2021-04-02 12:29
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.v
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Case Report
Article Title Melatonin for an obese child with MC4R gene variant showing epilepsy and disordered sleep: A case report
Manuscript Source Unsolicited Manuscript
All Author List Wen-Rong Ge, Lin Wan and Guang Yang
ORCID
Author(s) ORCID Number
Wen-Rong Ge http://orcid.org/0000-0002-1843-7302
Lin Wan http://orcid.org/0000-0002-2409-3497
Guang Yang http://orcid.org/0000-0001-8622-2146
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81671279
Big Data and Artificial Intelligence Research and Development Project of the Chinese PLA General Hospital 2019MBD-004
Corresponding Author Guang Yang, PhD, Professor, Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. yangguang74@301hospital.com.cn
Key Words Melanocortin receptor 4; Obesity; Sleep disorders; Epilepsy; Melatonin; Case report
Core Tip Numerous reports suggested that abnormalities of the MC4R (melanocortin receptor 4) gene may cause obesity, but are rarely associated with other conditions. The case presented in our manuscript involved a male obese child with a heterozygous variant in MC4R (c.494G>A, p.Arg165Gln) inherited from his father, who presented with epilepsy, sleep disordered and his melatonin rhythm was markedly distorted. This is the first report of the combination of these symptoms in a patient with an MC4R variant. Antiepileptic drug was ineffective and the sleep disorder appeared to be deteriorating. The use of melatonin relieved all his symptoms, and even the electroencephalography review was normal, and a typical melatonin rhythm was restored. We hope that our experience can help for the early diagnosis and treatment of this condition.
Publish Date 2021-04-02 12:29
Citation Ge WR, Wan L, Yang G. Melatonin for an obese child with MC4R gene variant showing epilepsy and disordered sleep: A case report. World J Clin Cases 2021; 9(11): 2688-2695
URL https://www.wjgnet.com/2307-8960/full/v9/i11/2688.htm
DOI https://dx.doi.org/10.12998/wjcc.v9.i11.2688
Full Article (PDF) WJCC-9-2688.pdf
Full Article (Word) WJCC-9-2688.docx
Manuscript File 61768-Review-FilipodiaCL .docx
Answering Reviewers 61768-Answering reviewers.pdf
Audio Core Tip 61768-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 61768-Conflict-of-interest statement.pdf
Copyright License Agreement 61768-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 61768-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 61768-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 61768-Language certificate.pdf
Peer-review Report 61768-Peer-review(s).pdf
Scientific Misconduct Check 61768-Bing-Wang JL-1.jpg
Scientific Misconduct Check 61768-Scientific misconduct check.pdf
Scientific Editor Work List 61768-Scientific editor work list.pdf