Publication Name	World Journal of Clinical Cases
Manuscript ID	61768
Country	China

Received	2020-12-21 11:29
Peer-Review Started	2020-12-18 01:47
To Make the First Decision
Return for Revision	2021-01-17 06:14
Revised	2021-01-18 05:36
Second Decision	2021-01-30 14:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-02-01 19:12
Articles in Press	2021-02-01 19:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-02-09 00:45
Typeset the Manuscript	2021-03-16 05:59
Publish the Manuscript Online	2021-04-02 12:29

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Neurosciences
Manuscript Type	Case Report
Article Title	Melatonin for an obese child with MC4R gene variant showing epilepsy and disordered sleep: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Rong Ge, Lin Wan and Guang Yang
ORCID	Author(s) ORCID Number Wen-Rong Ge http://orcid.org/0000-0002-1843-7302 Lin Wan http://orcid.org/0000-0002-2409-3497 Guang Yang http://orcid.org/0000-0001-8622-2146
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81671279 Big Data and Artificial Intelligence Research and Development Project of the Chinese PLA General Hospital 2019MBD-004
Corresponding Author	Guang Yang, PhD, Professor, Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. yangguang74@301hospital.com.cn
Key Words	Melanocortin receptor 4; Obesity; Sleep disorders; Epilepsy; Melatonin; Case report
Core Tip	Numerous reports suggested that abnormalities of the MC4R (melanocortin receptor 4) gene may cause obesity, but are rarely associated with other conditions. The case presented in our manuscript involved a male obese child with a heterozygous variant in MC4R (c.494G>A, p.Arg165Gln) inherited from his father, who presented with epilepsy, sleep disordered and his melatonin rhythm was markedly distorted. This is the first report of the combination of these symptoms in a patient with an MC4R variant. Antiepileptic drug was ineffective and the sleep disorder appeared to be deteriorating. The use of melatonin relieved all his symptoms, and even the electroencephalography review was normal, and a typical melatonin rhythm was restored. We hope that our experience can help for the early diagnosis and treatment of this condition.
Publish Date	2021-04-02 12:29
Citation	Ge WR, Wan L, Yang G. Melatonin for an obese child with MC4R gene variant showing epilepsy and disordered sleep: A case report. World J Clin Cases 2021; 9(11): 2688-2695
URL	https://www.wjgnet.com/2307-8960/full/v9/i11/2688.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i11.2688

Full Article (PDF)	WJCC-9-2688.pdf
Full Article (Word)	WJCC-9-2688.docx
CARE Checklist–2016	61768-CARE-Checklist–2016-revision.pdf
Manuscript File	61768-Review-FilipodiaCL .docx
Answering Reviewers	61768-Answering reviewers.pdf
Audio Core Tip	61768-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	61768-Conflict-of-interest statement.pdf
Copyright License Agreement	61768-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	61768-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	61768-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	61768-Language certificate.pdf
Peer-review Report	61768-Peer-review(s).pdf
Scientific Misconduct Check	61768-Bing-Wang JL-1.jpg
Scientific Misconduct Check	61768-Scientific misconduct check.pdf
Scientific Editor Work List	61768-Scientific editor work list.pdf