| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Network pharmacology-based analysis of heat clearing and detoxifying drug JC724 on the treatment of colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hua-Zhen Tang, Zhen-Peng Yang, Shuai Lu, Bing Wang, Yu-Ying Wang, Xi-Bo Sun, Jin-Xiu Qu and Ben-Qiang Rao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The National Natural Science Foundation of China |
82074061 |
| Beijing Natural Science Foundation Proposed Program |
7202076 |
|
| Corresponding Author |
Ben-Qiang Rao, Doctor, DPhil, PhD, Associate Chief Physician, Doctor, Doctor, Professor, Surgeon, Surgical Oncologist, Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Road, Yangfangdian, Haidian District, Beijing 100038, China. raobenqiang@bjsjth.cn |
| Key Words |
Heat-clearing and detoxifying therapy; Colorectal cancer; Network pharmacology; Transcriptomics |
| Core Tip |
We analyzed the core drug ingredients, genes and pathways of heat-clearing and detoxifying drug JC724 on the treatment of colorectal cancer (CRC), and illustrated the potential mechanisms comprehensively. We revealed that heat-clearing and detoxifying treatment can inhibit oxidative damage and inflammatory damage in CRC. |
| Publish Date |
2023-01-10 08:49 |
| Citation |
Tang HZ, Yang ZP, Lu S, Wang B, Wang YY, Sun XB, Qu JX, Rao BQ. Network pharmacology-based analysis of heat clearing and detoxifying drug JC724 on the treatment of colorectal cancer. World J Gastrointest Oncol 2023; 15(1): 90-101 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i1/90.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i1.90 |
