Publication Name	World Journal of Diabetes
Manuscript ID	65005
Country	Spain

Received	2021-02-26 11:08
Peer-Review Started	2021-02-26 11:14
To Make the First Decision
Return for Revision	2021-04-20 18:40
Revised	2021-05-08 07:56
Second Decision	2021-08-03 03:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-08-03 07:50
Articles in Press	2021-08-03 07:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-13 01:32
Typeset the Manuscript	2021-09-01 09:01
Publish the Manuscript Online	2021-09-07 08:15

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Ophthalmology
Manuscript Type	Review
Article Title	Cellular targets in diabetic retinopathy therapy
Manuscript Source	Invited Manuscript
All Author List	María Lucía Rodríguez, Iván Millán and Ángel Luis Ortega
ORCID	Author(s) ORCID Number María Lucía Rodríguez http://orcid.org/0000-0003-1809-4693 Iván Millán http://orcid.org/0000-0003-2049-5875 Ángel Luis Ortega http://orcid.org/0000-0002-9901-3383
Funding Agency and Grant Number
Corresponding Author	Ángel Luis Ortega, PhD, Associate Professor, Department of Physiology, Faculty of Pharmacy, University of Valencia, Av. Vicente Andrés Estellés, s/n, Burjassot 46100, Valencia, Spain. angel.ortega@uv.es
Key Words	Diabetic retinopathy; Oxidative stress; Inflammation; Cellular target; Diabetic macular edema
Core Tip	The identification of potential therapeutic targets related to oxidative stress and low chronic inflammation induced in diabetic retinopathy (DR) may be crucial in developing therapeutic approaches for preventing the development of DR. Hence, we focus on the following areas: the antioxidant role of nuclear factor erythroid 2-related factor 2, the low and chronic inflammatory conditions developed in DR, the modulation of lipid peroxidation, the activation of glucagon-like peptide-1 receptor, the classical biochemical pathways altered under hyperglycemia, and the epigenetic alterations.
Publish Date	2021-09-07 08:15
Citation	Rodríguez ML, Millán I, Ortega ÁL. Cellular targets in diabetic retinopathy therapy. World J Diabetes 2021; 12(9): 1442-1462
URL	https://www.wjgnet.com/1948-9358/full/v12/i9/1442.htm
DOI	https://dx.doi.org/10.4239/wjd.v12.i9.1442

Full Article (PDF)	WJD-12-1442.pdf
Full Article (Word)	WJD-12-1442.docx
Manuscript File	65005-Review-Filipodia-CL.docx
Answering Reviewers	65005-Answering reviewers.pdf
Audio Core Tip	65005-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65005-Conflict-of-interest statement.pdf
Copyright License Agreement	65005-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65005-Language certificate.pdf
Peer-review Report	65005-Peer-review(s).pdf
Scientific Misconduct Check	65005-CrossCheck.png
Scientific Misconduct Check	65005-Bing-Gong ZM-2.png
Scientific Misconduct Check	65005-Scientific misconduct check.pdf
Scientific Editor Work List	65005-Scientific editor work list.pdf
CrossCheck Report	65005-CrossCheck report.pdf